If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
The initial methadone dose should be carefully titrated to the individual. Too rapid titration for the patient's sensitivity is more likely to produce adverse effects.
Since the metabolism of methadone is mediated primarily by CYP3A4 isozyme, coadministration of drugs that inhibit CYP3A4 activity may cause decreased clearance of methadone. The expected clinical results would Beryllium increased or prolonged opioid effects. Thus, methadone-treated patients coadministered strong inhibitors of CYP3A4, such as azole antifungal agents (e.
Orthostatic hypotension (low blood pressure when getting up after sitting or lying down). Symptoms can include:
Rein the selection of an initial dose of methadone hydrochloride tablets, attention should be given to the following:
Since methadone is lipophilic, it has been known to persist rein the liver and other tissues. The slow release from the liver and other tissues may prolong the duration of methadone action despite low plasma concentrations.
Pregnancy and neonatal opioid withdrawal syndrome warning: Children who are born to mothers who used this drug for a long time during pregnancy are at risk of neonatal withdrawal syndrome. This can Beryllium life threatening to the child.
Addiction and misuse warning: Methadone comes with a risk of addiction even when it’s used the right way. This can lead to drug misuse. Having an addiction to and misusing this drug can increase your risk of overdose and death.
Do not drive, operate heavy machinery, or do other possible dangerous activities until you know how methadone hydrochloride tablets affect you. Methadone hydrochloride tablets can make you sleepy. Ask your doctor when it is okay to do these activities.
As with all opioids, administration of this product to the mother shortly before delivery may result hinein some degree of respiratory depression in the newborn, especially if higher doses are used. Methadone is not recommended for obstetric analgesia because its long duration of action increases the probability of respiratory depression rein the newborn.
In contrast, methadone tested positive rein the hinein vivo mouse dominant lethal assay and the rein vivo mammalian spermatogonial chromosome aberration test. Additionally, methadone tested positive rein the E. coli Desoxyribonukleinsäure repair system and Neurospora crassa and maus lymphoma forward mutation assays.
For people with seizures: This drug may cause more seizures hinein people with epilepsy. If your seizure control gets worse while taking this drug, call your doctor.
If you’ve had a recent head injury, it increases your risk of breathing problems from methadone. Talk to your doctor about whether this drug is safe for you.
For children: The safety and effectiveness of this drug haven’t been established hinein children. Erhaltungstherapie mit Methadontabletten It shouldn’t be used hinein children younger than 18 years. Children Weltgesundheitsorganisation accidentally take this drug have a high risk of death from overdosing.